For Her

•Inositol is a vitamin-like substance. It is found in many plants and animals. It is also produced in the human body and can be made in a laboratory. Inositol can be found in many forms (called isomers). The most common forms are myo-inositol and D-chiro-inositol
•Inositol is used to for metabolic syndrome and polycystic ovary syndrome (PCOS).

(Metabolic syndrome is a group of risk factors — high blood pressure, high blood sugar, high triglycerides, low HDL cholesterol, and belly fat — that increases risk of heart disease and diabetes. Diet, exercise, and medications can help improve it.)

How does it work ?

•Inositol might balance certain chemicals in the body to possibly help with mental conditions such as panic disorder, depression, and obsessive-compulsive disorder. It might also help insulin work better. This might help with conditions such as polycystic ovary syndrome or diabetes during pregnancy.
•Myo-inositol is a member of the vitamin B-complex group. It is found in a wide variety of foods including fresh fruits, beans, whole grains and seeds. Myo-inositol has been used in the treatment of diabetic neuropathy, depression, Alzheimer’s disease, panic disorder and polycystic ovary syndrome (PCOS).
•Myo-inositol is taken orally as a supplement. It is well tolerated and appears safe when used at doses up to 12 grams per day. The longest reported utilization of myo-inositol for enhancing fertility is 12 months. Common side effects may include nausea fatigue, dizziness and insomnia. Myo-inositol’s can be beneficial in improving fertility because of its effectiveness in women with PCOS, in vitro fertilization (IVF) procedures and pregnancy.

•Facts about myo-inositol:

  1.  Myo-inositol is a dietary supplement available without prescription
  2.  Myo-inositol appears safe and non-toxic
  3.  The typical treatment dose is 2 grams with 400 micrograms of folic acid twice daily; a mixture of myo-inositol with D-chiro-inositol (40:1) appears to be the most effective form
  4.  In patient with PCOS, a high percentage of women taking myo-inositol will establish regular periods and show evidence of ovulation
  5. For IVF patients, no standard time for pretreatment with myo-inositol has been established, though the majority of studies begin  1- 3 months before the actual IVF cycle
  6.  Emerging evidence shows promise for the use of the supplement in the reduction/prevention of gestational diabetes (GDM) in patients with PCOS or those at risk due to GDM or prior family history.

Myo-inositol and PCOS

•Many patients with PCOS are insulin resistant. Myo-inositol has been used as a supplement in patients with PCOS based on this observation. It is classified as an insulin-sensitizing agent which acts to regulate a number of cellular functions including improved insulin utilization. It appears at least as effective as metformin, another insulin-sensitizing drug.
•In women with PCOS, myo-inositol improves insulin sensitivity and reduces insulin levels. Clinical studies have shown that both myo-inositol and D-chiro-inositol may also:
•Decrease serum androgens (male hormones)
•Decrease triglycerides
•Increase HDL cholesterol (the good cholesterol)
•Lower systolic and diastolic blood pressure.
•A recent study published in February 2015 again demonstrated the effectiveness of myo-inositol in patents with PCOS. Fifty women with PCOS, insulin resistance and lack of ovulation were given the drug. Twenty-nine of the 50 women showed evidence of ovulation and 11 (37.9%) became pregnant. In the patients who did not ovulate on myo-inositol alone, 13 of the 18 showed an ovulatory response when clomiphene was added and six (42.6%) conceived.

Myo-inositol and IVF

•Non-PCOS IVF patients receiving 4 grams of myo-inositol with 800 micrograms of folic acid daily have demonstrated a reduction in the amount of follicle-stimulating hormone (FSH) administered and a reduction in the total number of mature oocytes obtained, with no resulting change in clinical pregnancy rates.
•In studies of PCOS patients undergoing IVF, pretreatment with 4 grams of myo-inositol with 800 mcg daily of folic acid resulted in less total FSH used for stimulation. Pregnancy rates may be improved (this is a trend, but not statistically significance).

Myo-inositol and Pregnancy

•A recent Italian study just published reports a 66 percent reduction in the incidence of gestational diabetes in obese women (BMI 30 or >) who took myo-inositol (2 grams myo-inositol + 200 mcg folic acid twice daily). The supplementation was started in the first trimester and continued until delivery. The authors propose that the reduction was due to improved insulin sensitivity.

How does myo-inositol work?

•Myo-inositol reduces androgen (male hormone levels). In hyper-androgenic PCOS patients, that may represent a significant benefit. In many other women with infertility, such as women with premature ovarian aging (POA, also called occult primary ovarian insufficiencyor oPOI) or in women with hypo-androgenic PCOS (H-PCOS), both conditions where women actually have abnormally low androgen levels, this hypo-androgenism may be exacerbated by myo-inositol supplementation.
•CHR, therefore, does not recommend automatic myo-inositol supplementation since it may counteract androgen supplementation in women with POA/oPOIand H-PCOS, which at CHR is routine since ovaries must have normal testosterone levels within the ovarian micro-environment in order to produce good quality eggs at maximum numbers.
•Polycystic ovary syndrome (PCOS) is a condition that causes hormone imbalances in women, which may lead to irregular periods and infertility. Weight gain, high blood sugar and undesirable cholesterol and triglyceride levels are also concerns with PCOS.
•Inositol supplements may improve PCOS symptoms, particularly when combined with folic acid.
•For instance, clinical studies suggest that daily doses of inositol and folic acid may help reduce levels of triglycerides in the blood. They may also improve insulin function and slightly lower blood pressure in those with PCOS.
•What’s more, preliminary research found that the combination of inositol and folic acid may promote ovulation in women with fertility issues from PCOS .
•In one study, 4 grams of inositol and 400 mcg of folic acid taken daily for 3 months induced ovulation in 62% of treated women .
•Myoinositol supplement increase clinical pregnancy rate in infertile women undergoing ovulation induction for ICSI or IVF-ET. It may improve the quality of embryos, and reduce the unsuitable oocytes and required amount of stimulation drugs.

L arginine & L carnitine

•L-arginine and L-carnitine are two important amino acids that are synthesized in separate parts of your body and found in a variety of foods. Both amino acids are sold in supplement form and used for a variety of similar and different health-promoting purposes. Despite the relative safety of these amino acids, large doses might cause unwanted side effects, and you should talk to your doctor before taking any new supplement.
• l arginine
•Increase uterine areterial blood flow and vascular perfusion of the preovulatory follicle
•Increased vascular perfusion of the preovulatory follicle has been correlated with successful pregnancy

Carnitine

•Carnitine burns fat by transporting fatty acids into the mitochondria inside cells, where the fats are converted into energy. It also transports toxic wastes out of the mitochondria. Large concentrations of carnitine are found in skeletal and cardiac muscle. Carnitine may help lower the pain associated with diabetic neuropathy and reduce the symptoms of an overactive thyroid.
•It helps in to achieve greater thickness of the endometrium

Folic Acid

•CDC urges all women of reproductive age to take 400 micrograms (mcg) of folic acid each day, in addition to consuming food with folate from a varied diet, to help prevent some major birth defects of the baby’s brain (anencephaly) and spine (spina bifida).
•About folic acid
•Folic acid is a B vitamin. Our bodies use it to make new cells. Think about the skin, hair, and nails. These–and other parts of the body – make new cells each day. Folic acid is the synthetic (that is, not generally occurring naturally) form of folate used in supplements and in fortified foods such as rice, pasta, bread, and some breakfast cereals

Zinc

•Zinc supports fertility by regulating normal hormone function,our bodies didn’t store zinc so its important to take it daily
•Zinc plays important role in oocyt division ,fertilization ,dna regulation and embryo development.

Coenzyme Q10

•Your body produce coenzyme q10 & l carnitine on its own .but increasing its amount in your blood stream have benefit for baby making ,especially if you were trying ivf
•Pre supplementation with coq10 improved ovarian response in women undergoing ivf,if surprisingly increases ovarian stimulation ,egg quality &mitochondrial function

Vitex

•may improve female fertility due to its possible effect on prolactin levels .
•This may be especially true in women with luteal phase defect, or a shortened second half of the menstrual cycle. This disorder is linked to abnormally high prolactin levels and makes it difficult for women to become pregnant.
•In one study, 40 women with abnormally high prolactin levels were given either 40 mg of Vitex agnus-castus or a pharmaceutical drug. Vitex was as effective as the drug in reducing prolactin levels .
•In another study in 52 women with luteal phase defect, 20 mg of vitex resulted in lower prolactin levels and prolonged menstrual phases, while participants given a placebo saw no benefits .
•Yet another study gave 93 women — who had unsuccessfully tried to become pregnant over the last 6–36 months — a supplement containing Vitex agnus-castus or a placebo.
•After three months, women in the vitex group experienced an improved hormone balance — and 26 percent of them became pregnant. In comparison, only 10 percent of those in the placebo group became pregnant .
•eep in mind that the supplement held a mix of other ingredients, making it difficult to isolate the effects of vitex.
•Irregular periods can also hamper women in planning a pregnancy. Three additional studies report that vitex is more effective than a placebo in improving menstrual cycles in women with irregular periods.
•In herbal medicine, vitex, also known as chaste tree, is sometimes used to treat amenorrhea. Research suggests it may regulate hormones related to menstruation and fertility. More. In herbal medicine, vitex (Vitex agnus-castus; chaste tree) is sometimes used to treat female infertility and amenorrhea.

BetA CAROTENE

• The body converts Beta Carotene into vitamin A (retinol). Vitamin A, known as a vital nutrient for vision, plays a critical role in cell growth and in maintaining healthy organs like the heart, lungs, and kidneys.Oct 13, 2020
•HAS INTENES ANTIOXIDANT ACTIVITY ,beta carotene is essential for ovarian function ,for growth and deffrentiation of anumber of cell and tisues and has important role in the healthy development of the fetus and newborn.
•s an antioxidant. An antioxidant is a substance that inhibits the oxidation of other molecules; it protects the body from free radicals.
•Free radicals damage cells through oxidation. Eventually, the damage caused by free radicals can cause several chronic illnesses.

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